What does the SSL Handshake error with a remote server indicate when using Node.js with Apache?

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The SSL handshake error with a remote server when using Node.js with Apache indicates that there is a problem with the SSL/TLS handshake process between the client (Node.js) and the server (Apache). This can occur if the SSL certificate used by the server is either expired or invalid, or if the server is using a different SSL protocol or cipher suite than what the client supports. This error can also occur if the SSL certificate chain is incomplete or if there are other errors with the SSL configuration on the server.