Is it possible for a subdomain to be directed to a hosting service different from the main domain?

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Yes, it is possible for a subdomain to be directed to a hosting service different from the main domain. This can be done by changing the DNS records for the subdomain to point to a different server or hosting provider. However, it is important to ensure that the hosting provider is set up to handle the subdomain properly and that any necessary configuration changes are made to ensure the subdomain functions as intended.