No, it is not possible to establish a connection to Hive2 via Beeline if the port 10000 is not being listened to. This is because the port 10000 is the default port on which the Hive server listens for client requests. If the port is not open, the client will not be able to connect to the Hive server. It is important to ensure that the port is open and accessible before attempting to establish a connection to Hive2 via Beeline.
