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It is impossible to give a definitive answer to this question without knowing specific details about the variables and context involved. The range of variables that would lead to the highest profit and loss would depend on numerous factors, such as the type of business, market conditions, competition, pricing strategies, and more. Additionally, the concept of "highest profit and loss" is somewhat contradictory, as profit and loss are opposing outcomes. A company may aim for high profits, but not at the cost of high losses. Ultimately, a detailed analysis would be needed to determine the optimal range of variables for maximizing profitability while minimizing losses.