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In order to allow several users to update an HTML form and MySQL database simultaneously, you can implement the following best practices:

1. Use a web application framework such as Ruby on Rails, Django, or Laravel that provides efficient and secure methods for handling user input and database transactions.

2. Implement a locking mechanism to prevent two or more users from concurrently modifying the same record in the database. This can be achieved by using MySQL's transaction isolation level or by implementing a custom locking mechanism in your web application.

3. Use AJAX or WebSockets to allow real-time updates when multiple users are accessing the same form or database. This can provide a smoother user experience and minimize conflicts between different users' updates.

4. Add proper error handling and validation to the HTML form to prevent users from submitting incorrect or invalid data to the database.

5. Use a load balancer and replicate servers to handle heavy traffic and ensure that multiple users can access and update the form and database at the same time without any lag or downtime.