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There are several potential problems that can be encountered when attempting to connect to AWS Elasticache using StackExchange.Redis:

1. Authentication: Elasticache requires authentication to connect. It's necessary to provide the correct credentials in the connection string.

2. VPC configuration: Elasticache can be configured to be accessed only from certain VPCs or IP addresses. It's necessary to ensure that the client attempting to connect is within the allowed network or have configured VPC peering correctly.

3. Security groups: ensure the security group attached to your Elasticache instance allows incoming traffic to the specified port used by Redis (default is 6379).

4. Endpoint: the endpoint and port number in the connection string to Amazon Elasticache must be correct.

5. Redundancy: it's recommended to configure the StackExchange.Redis client to handle node failures with auto-discovery feature.

6. Version mismatch: the version of the StackExchange.Redis client must be compatible with the version of Redis running on the Elasticache instance.

Additional checks can be done on the instance logs and client-side logs to help diagnose and correct issues.