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One possible solution in Python is:

my_string = "apple, banana, cherry, date, elderberry"
my_list = my_string.split(", ")
new_list = my_list[:-2]
new_string = ", ".join(new_list)
print(new_string)

This code first defines a sample input string my_string that contains comma-separated values. It then splits this string into a list of individual items using the split() method, assuming that items are separated by a comma and a space. For example, the resulting list my_list would be ['apple', 'banana', 'cherry', 'date', 'elderberry'].

Next, we create a new list new_list that takes all items from my_list except the last two, which are sliced off using the notation [:-2]. This way, new_list would be ['apple', 'banana', 'cherry'].

Finally, we convert new_list back to a string using the join() method, with a comma and a space as the separator between items. The resulting string new_string is then printed, which would be 'apple, banana, cherry'.

Note that this approach assumes that the input string always has at least two items to remove. If the string has fewer than two items or no commas at all, the code may not work as intended. Other variations and error-checking mechanisms may be needed depending on the specific use case.