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When there is an error while loading the pickle in an ANN model, it means that there was an issue in loading the previously saved model. Pickle is a module in Python that is used to serialize and de-serialize Python objects. Therefore, when a model is saved in a pickle format, it is expected to be loaded successfully without errors.

However, if there is an error while loading the pickle in an ANN model, it could be due to several reasons such as incompatible versions of Python or packages used in the original model, incorrect path or file name, corrupted pickle file, etc. The error message would provide more information on the specific issue causing the error.