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There could be several possible causes of a Python SQLite3 table disappearing inexplicably:

1. Accidental Deletion: The table could have been accidentally deleted by someone with sufficient privileges.

2. Corruption: If the database file or the table file is corrupt, it could cause the table to disappear.

3. Update or Upgrade: If the SQLite3 database is updated or upgraded, it could cause the table to disappear if there are compatibility issues.

4. Misconfiguration: If the database schema or settings are not correctly configured, it could cause the table to disappear.

5. Malware or Viruses: If a malicious virus or malware infiltrates the system, it could cause the table to disappear.

6. Hardware or Software Malfunction: A malfunctioning hard drive, failed operating system update, or an incompatible software update could cause loss of the table.

It is always a good practice to back up the SQLite3 database regularly and maintain proper security protocols.