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Yes, it is possible to establish an ODBC connection in Google Colab. You can use the pyodbc library to create a connection to an ODBC data source. First, you need to install the necessary ODBC driver and set up the data source on your local machine. Then, you can use the following code to create a connection in Google Colab:

import pyodbc

# Establish a connection to the ODBC data source
conn = pyodbc.connect('DRIVER={ODBC Driver}; \
                      SERVER=your_server; \
                      DATABASE=your_database; \
                      UID=your_username; \
                      PWD=your_password')

Replace ODBC Driver, your_server, your_database, your_username, and your_password with the appropriate values for your data source.