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Yes, it is possible to transform data from a pdf into a DataFrame using Python. We can use various packages such as PyPDF2, pdfminer, and others to extract data from a pdf file. Once we have extracted the data, we can convert it into a DataFrame using pandas. However, the success of this process often depends on the structure and format of the pdf file. If the pdf file is formatted in a way that is difficult to parse, the extraction process may be challenging.