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Yes, there is a compatibility issue between Hyper-V and VirtualBox when running Minikube with Docker. This is because both Hyper-V and VirtualBox use different virtualization technologies, which may interfere with each other and cause conflicts.

To avoid this issue, it is recommended to choose either Hyper-V or VirtualBox as the virtualization technology for Minikube, and not to switch between them. It is also important to ensure that the chosen virtualization technology is properly configured and supported by Minikube.