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There could be several reasons why a Universal Windows Platform (UWP) app may not run outside of Visual Studio:

1. Missing dependencies: UWP apps have certain dependencies such as the .NET framework and certain Windows Runtime components. If these dependencies are not installed on the target machine, the app will not run.

2. Unsupported architecture: UWP apps can be compiled for different processor architectures such as x86, x64, ARM, and ARM64. If the target machine has a different architecture than the one the app was compiled for, it will not run.

3. Security restrictions: UWP apps run in a sandboxed environment with limited access to system resources. If the app requires access to resources that are not allowed by the current security policy of the target machine, it will not run.

4. Configuration issues: UWP apps may require specific configuration settings such as app permissions, certificates, or package identities. If these settings are not correctly configured, the app will not run.

5. App errors: Finally, the app itself may have errors or bugs that prevent it from running correctly. As such, it is important to test the app thoroughly in Visual Studio and address any issues before attempting to run it outside of the development environment.