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No, it is not possible to open a PDF file that is contained within a ZIP folder using fitz.open(). You will need to first extract the PDF file from the ZIP folder and then open it using fitz.open(). Here is an example of how to extract a PDF file from a ZIP folder using Python:

import zipfile

# Open the ZIP folder
with zipfile.ZipFile("myzip.zip", "r") as myzip:

    # Extract the PDF file
    myzip.extract("mypdf.pdf")

# Open the PDF file with PyMuPDF
import fitz

doc = fitz.open("mypdf.pdf")