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To activate virtualenv within a Makefile, you can use the following command:

venv:
    . path/to/virtualenv/bin/activate && pip install -r requirements.txt

This command first activates the virtual environment by sourcing the activate script, and then installs the required packages from the requirements.txt file using pip. The . activate command ensures that the subsequent pip commands are executed within the virtual environment. You can then run this command by typing make venv in your terminal/shell.