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React is a JavaScript library that relies heavily on JavaScript to render its components and interact with the user. If the browser's JavaScript functionality is disabled, React will not be able to load the page and will display the message "You must enable JavaScript to execute this app". This message indicates that the browser is not able to execute JavaScript, and the page cannot function as intended without it. Therefore, it's necessary to enable JavaScript in the browser to ensure that the React app can load and function properly.