Is it impossible to install the wheel for cffi-1.15.1-cp36-cp36m-win_amd64 on Python 3.10?

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It is possible that the wheel for cffi-1.15.1-cp36-cp36m-win_amd64 may not be compatible with Python 3.10 because it was built specifically for Python 3.6 (as indicated by the cp36 in the wheel filename). However, this does not necessarily mean that it is impossible to install the wheel on Python 3.10. You may try installing it and see if it works, or you can try building cffi from source on Python 3.10.