Is it possible to have distinct front-end and back-end applications within the same domain?

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Yes, it is possible to have distinct front-end and back-end applications within the same domain. For example, a website might have a front-end application built with React or Angular, and a back-end application built with Node.js, Django, or another server-side technology. The two applications can communicate with each other through APIs or other means, and the user would interact with the website as a single entity.