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One common issue encountered when attempting to run GDAL scripts using Python3 on macOS 12 (Monterey) is that the pre-installed Python3 version may not have the necessary GDAL dependencies installed, leading to errors when attempting to import GDAL modules or use GDAL functions in scripts. It may be necessary to install GDAL and its dependencies manually using package managers such as Homebrew or Anaconda, or to use a virtual environment to manage dependencies separately from the system Python installation. Additionally, there may be issues with compatibility between GDAL versions and macOS 12, which can cause errors or crashes when running scripts.