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Yes, collision checks can be performed in WPF. There are several ways to perform collision checks in WPF, including:

1. Using the Geometry class to create shapes and checking for intersections between them.
2. Using Hit Testing to detect if any elements in a visual tree intersect with a specific point or region.
3. Using the VisualTreeHelper class to traverse the visual tree and check for intersections between elements.

With these methods, you can perform collision checks between elements such as shapes, images, and other visual elements.